Factors influencing sib risks for multiple sclerosis. The Canadian Collaborative Study Group

 

Sadovnick AD, Yee IM, Ebers GC
Department of Medical Genetics, University of British Columbia, Vancouver, Canada

Multiple sclerosis (MS) is now thought to be a complex trait determined by genetic and non-genetic (environmental) factors. The study group, identified from the Canadian Collaborative Project on Genetic Susceptibility to MS, consisted of 1,083 MS index cases, 2,166 of their parents and 3,112 of their sibs. The results, together with those of a previous study on an independent data set, suggest that gender, age of MS onset and having one parent with MS may individually and interactively alter sib risks for MS. These data are important for genetic counseling and for molecular genetic (genome screens, candidate gene analyses) studies.
Clin Genet 2000 Dec;58(6):431-5

Source: www.ncbi.nlm.nih.gov

 

  This material is provided as general medical information and is not intended as advice for individual patients; please contact your physician for specific recommendations.

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